Ma\u010dji infekcijski peritonitis (FIP) je ena od najbolj raz\u0161irjenih ma\u010djih infekcijskih bolezni na svetu in \u0161e vedno predstavlja diagnosti\u010dni “izziv” za veterinarje. Dokon\u010dna diagnoza ni enostavna “in vivo”, saj je treba dokazati tako klasi\u010dne klini\u010dno-patolo\u0161ke spremembe bolezni kot povzro\u010ditelja (koronavirus).<\/p>\n
Med beljakovinami akutne faze je alfa-1-kisli glikoprotein (AGP) v preteklosti veljal za najbolj uporabnega za diagnozo FIP, vendar v zadnjih letih metoda, ki se je uporabljala za njegovo merjenje (radialna imuno-difuzija), ni ve\u010d na voljo.<\/p>\n
Kon\u010dno bo od leta 2023 v na\u0161em laboratoriju mogo\u010de meriti alfa-1-kisli glikoprotein (AGP) v ma\u010djih serumih z metodo ELISA, ki je bila nedavno potrjena pri tej vrsti.<\/p>\n
Alfa-1-kisli glikoprotein (AGP) je beljakovina akutne faze (APP). Njena koncentracija se zato med vnetnim procesom pove\u010da. Pri ma\u010dkah se lahko AGP meri z imunolo\u0161kimi metodami (npr: ELISA), ki pa zahtevajo specifi\u010dna protitelesa za ma\u010djo beljakovino, saj uporaba protiteles, razvitih pri drugih vrstah, zazna druge beljakovine kot ma\u010dji AGP in zato daje rezultate, ki ne ustrezajo dejanski koncentraciji molekule. Ve\u010d let ni bilo mogo\u010de natan\u010dno dolo\u010diti AGP, ker je bil radialni imuno-difuzijski komplet, ki je veljal za edinega, ki je lahko prepoznal ma\u010dji AGP, izlo\u010den iz proizvodnje. Pred kratkim pa je bil razvit test ELISA z ustrezno natan\u010dnostjo in to\u010dnostjo za diagnosti\u010dno uporabo.<\/p>\n
Med beljakovinami akutne faze se AGP pri skoraj vseh vrstah obna\u0161a kot manj\u0161i ali zmerni APP. Njeno pove\u010danje je koli\u010dinsko omejeno: v primeru vnetega procesa je zaznati 4-5-kratno pove\u010danje obi\u010dajnih koncentracij (v krvi zdravih oseb je pri skoraj vseh vrstah prisotna v koncentracijah, manj\u0161ih od 0,5 mg\/ml).<\/p>\n
Tudi pri ma\u010dki se pri ve\u010dini blagih ali nespecifi\u010dnih vnetih stanj AGP v serumu zmerno pove\u010da. Izjema je ma\u010dji infekcijski peritonitis (FIP), pri katerem se koncentracija AGP v serumu pogosto znatno pove\u010da (od 3- do 10-kratnik obi\u010dajne koncentracije).<\/p>\n
Zaradi tega je AGP zelo mo\u010dno diagnosti\u010dno orodje pri FIP, tako mokrem kot suhem, in je med APP izbrani marker za razlikovanje te bolezni od drugih vnetnih ali infekcijskih stanj s podobno simptomatiko.<\/p>\n
\u010ceprav se med FIP pove\u010da tudi koncentracija drugih vnetnih beljakovin, kot sta serumski amiloid A (SAA) in haptoglobin (Hp), so pove\u010danja slednjih zelo nespecifi\u010dna: zlasti SAA se zelo pove\u010da (deset- do stokratnik normalnih vrednosti) tako med FIP kot med drugimi vnetnimi boleznimi, Hp pa se zmerno do blago pove\u010da tako med FIP kot med drugimi boleznimi.<\/p>\n
Zato omenjenih APP ni mogo\u010de uporabiti za razlikovanje med FIP in drugimi boleznimi s podobnim potekom. Seveda lahko tudi med potekom FIP ob\u010dasno opazimo zmerno pove\u010danje AGP, vendar je \u0161e vedno nad normalnimi vrednostmi. V tem primeru je pomembno povezati pove\u010danje AGP s simptomatsko sliko in vsemi drugimi laboratorijskimi spremembami, ki so skladne s FIP, predvsem z elektroforezo beljakovin v serumu, ki pri FIP ka\u017ee vrhove globulinov alfa 2 in gama, in citokemi\u010dno sliko izliva (z visoko vsebnostjo beljakovin, razmerjem albumin\/globulin < 1,0, visokim razmerjem LDH\/TNCC in nespecifi\u010dno vnetno citologijo, za katero so zna\u010dilni predvsem nedegenerirani nevtrofilci in zrnato beljakovinsko ozadje), morda povezano s pozitivnim PCR za koronavirus, ki je sicer lahko negativen pri pribli\u017eno tretjini ma\u010dk s FIP (ob\u010dutljivost PCR na izliv pribli\u017eno 70 %), vendar \u010de je pozitiven, potrdi diagnozo (specifi\u010dnost PCR na izlivu je skoraj 100 %).\n\n\u010ce so vrednosti AGP znotraj referen\u010dnih razponov, je treba izklju\u010diti FIP in poiskati druge vzroke za vse ugotovljene simptome. Podobno ni koristno meriti AGP pri zdravih ma\u010dkah, ki so serolo\u0161ko pozitivne na koronavirus, da bi posku\u0161ali napovedati razvoj FIP.\n\nAGP je dejansko vnetni ozna\u010devalec in tudi \u010de je ma\u010dka seropozitivna, je njegova koncentracija v serumu normalna, dokler se ne razvije vnetje, povezano z boleznijo, povzro\u010deno s koronavirusom. Z drugimi besedami, pove\u010danje AGP se pojavi \u0161ele po pojavu simptomov in ne prej. Nedavna \u0161tudija, izvedena v dr\u017eavah, v katerih se lahko predpisuje in izvaja zdravljenje z nukleozidnimi analogi za boj proti FIP, je pokazala, da se AGP pri ma\u010dkah, ki se odzivajo na zdravljenje, normalizira prej kot drugi laboratorijski parametri, medtem ko pri ma\u010dkah, pri katerih zdravljenje ne daje \u017eelenih rezultatov, ostane nespremenjen.\n\n![\"PIF\"](\"https:\/\/www.mylav.net\/wp-content\/uploads\/2022\/12\/blog_PIF_it.png\")
<\/p>\n
Zato je dolo\u010danje AGP priporo\u010dljivo ne le pri vsakem vnetnem procesu, pri katerem obi\u010dajno poka\u017ee skromno povi\u0161anje v skladu s tistimi pri drugih FIP, temve\u010d zlasti takrat, ko ugotovljeni simptomi vodijo do klini\u010dnega suma na suhi ali mokri FIP: \u010ce so vrednosti AGP znotraj referen\u010dnih razponov, se lahko FIP izklju\u010di, \u010de pa so vrednosti zmerno povi\u0161ane, je treba FIP obravnavati kot mo\u017eno, \u010de to potrjujejo druge klini\u010dne ali laboratorijske spremembe, \u010de so vrednosti povi\u0161ane, je lahko AGP diagnosti\u010dno potrditveno orodje, \u010de pa je mo\u017eno zdravljenje z dovoljenimi protivirusnimi zdravili, se lahko \u0161teje za idealnega ozna\u010devalca za spremljanje zdravljenja in prepoznavanje “odzivnikov”.<\/p>\n
\n
Bibliografija:<\/h5>\n
Addie DD et al (2022) Alpha-1 Acid Glycoprotein Reduction Differentiated Recovery from Remission in a Small Cohort of Cats Treated for Feline Infectious Peritonitis. Viruses. Apr 1;14(4): 744. doi: 10.3390\/v14040744<\/p>\n
Hazuchova K et al (2017) Usefulness of acute phase proteins in differentiating between feline infectious peritonitis and other diseases in cats with body cavity effusions. J Feline Med Surg. Aug;19(8):809-816. doi: 10.1177\/1098612X16658925. Epub 2016 Jul 18.<\/p>\n
Paltrinieri S et al (2007) Critical assessment of the diagnostic value of feline alpha1-acid glycoprotein for feline infectious peritonitis using the likelihood ratios approach. J Vet Diagn Invest. May;19(3): 266-72.<\/p>\n
Saverio Paltrinieri<\/strong>, Med. Vet. EBVS European Specialist in Veterinary Clinical Pathology (Dipl. ECVCP); Universit\u00e0 di Milano
\nWalter Bertazzolo<\/strong>, Med. Vet. EBVS European Specialist in Veterinary Clinical Pathology (Dipl. ECVCP); Direttore Scientifico di MYLAV\n<\/div>\n","protected":false},"excerpt":{"rendered":"Ma\u010dji infekcijski peritonitis (FIP) je ena od najbolj raz\u0161irjenih ma\u010djih infekcijskih bolezni na svetu in […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-25838","post","type-post","status-publish","format-standard","hentry"],"acf":[],"yoast_head":"\n
VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN) - MyLav<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN) - MyLav\" \/>\n<meta property=\"og:description\" content=\"Ma\u010dji infekcijski peritonitis (FIP) je ena od najbolj raz\u0161irjenih ma\u010djih infekcijskih bolezni na svetu in […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/\" \/>\n<meta property=\"og:site_name\" content=\"MyLav\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/laboratoriolavallonea\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-10T11:53:46+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-08T17:04:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.mylav.net\/wp-content\/uploads\/2022\/12\/blog_PIF_it.png\" \/>\n<meta name=\"author\" content=\"epops\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"epops\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minut\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/\"},\"author\":{\"name\":\"epops\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#\\\/schema\\\/person\\\/1f212c868d6970154f91b93e9741dddb\"},\"headline\":\"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN)\",\"datePublished\":\"2022-12-10T11:53:46+00:00\",\"dateModified\":\"2024-02-08T17:04:49+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/\"},\"wordCount\":971,\"publisher\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.mylav.net\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/blog_PIF_it.png\",\"inLanguage\":\"sl-SI\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/\",\"url\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/\",\"name\":\"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN) - MyLav\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.mylav.net\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/blog_PIF_it.png\",\"datePublished\":\"2022-12-10T11:53:46+00:00\",\"dateModified\":\"2024-02-08T17:04:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/#breadcrumb\"},\"inLanguage\":\"sl-SI\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"sl-SI\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.mylav.net\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/blog_PIF_it.png\",\"contentUrl\":\"https:\\\/\\\/www.mylav.net\\\/wp-content\\\/uploads\\\/2022\\\/12\\\/blog_PIF_it.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/nekategorizirano-sl\\\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#website\",\"url\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/\",\"name\":\"MyLav\",\"description\":\"vicini al tuo veterinario, vicini alla tua famiglia\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"sl-SI\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#organization\",\"name\":\"MyLav\",\"alternateName\":\"MyLav\",\"url\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"sl-SI\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.mylav.net\\\/wp-content\\\/uploads\\\/2019\\\/02\\\/logo_mylav.svg\",\"contentUrl\":\"https:\\\/\\\/www.mylav.net\\\/wp-content\\\/uploads\\\/2019\\\/02\\\/logo_mylav.svg\",\"width\":\"1024\",\"height\":\"1024\",\"caption\":\"MyLav\"},\"image\":{\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/laboratoriolavallonea\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/mylav\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCPinPLKBkenJ_QlDKxXXjCA\",\"https:\\\/\\\/open.spotify.com\\\/show\\\/42D6N8rL6JzgjCfVnroMzp\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.mylav.net\\\/sl\\\/#\\\/schema\\\/person\\\/1f212c868d6970154f91b93e9741dddb\",\"name\":\"epops\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"sl-SI\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/5b1686ccefcf94bad1a337443165cdc8836f3ded7fcc6aaf18c657018c423ad3?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/5b1686ccefcf94bad1a337443165cdc8836f3ded7fcc6aaf18c657018c423ad3?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/5b1686ccefcf94bad1a337443165cdc8836f3ded7fcc6aaf18c657018c423ad3?s=96&d=mm&r=g\",\"caption\":\"epops\"},\"sameAs\":[\"https:\\\/\\\/www.epops.it\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN) - MyLav","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/","og_locale":"sl_SI","og_type":"article","og_title":"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN) - MyLav","og_description":"Ma\u010dji infekcijski peritonitis (FIP) je ena od najbolj raz\u0161irjenih ma\u010djih infekcijskih bolezni na svetu in […]","og_url":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/","og_site_name":"MyLav","article_publisher":"https:\/\/www.facebook.com\/laboratoriolavallonea\/","article_published_time":"2022-12-10T11:53:46+00:00","article_modified_time":"2024-02-08T17:04:49+00:00","og_image":[{"url":"https:\/\/www.mylav.net\/wp-content\/uploads\/2022\/12\/blog_PIF_it.png","type":"","width":"","height":""}],"author":"epops","twitter_card":"summary_large_image","twitter_misc":{"Written by":"epops","Est. reading time":"5 minut"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/#article","isPartOf":{"@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/"},"author":{"name":"epops","@id":"https:\/\/www.mylav.net\/sl\/#\/schema\/person\/1f212c868d6970154f91b93e9741dddb"},"headline":"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN)","datePublished":"2022-12-10T11:53:46+00:00","dateModified":"2024-02-08T17:04:49+00:00","mainEntityOfPage":{"@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/"},"wordCount":971,"publisher":{"@id":"https:\/\/www.mylav.net\/sl\/#organization"},"image":{"@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/#primaryimage"},"thumbnailUrl":"https:\/\/www.mylav.net\/wp-content\/uploads\/2022\/12\/blog_PIF_it.png","inLanguage":"sl-SI"},{"@type":"WebPage","@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/","url":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/","name":"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN) - MyLav","isPartOf":{"@id":"https:\/\/www.mylav.net\/sl\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/#primaryimage"},"image":{"@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/#primaryimage"},"thumbnailUrl":"https:\/\/www.mylav.net\/wp-content\/uploads\/2022\/12\/blog_PIF_it.png","datePublished":"2022-12-10T11:53:46+00:00","dateModified":"2024-02-08T17:04:49+00:00","breadcrumb":{"@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/#breadcrumb"},"inLanguage":"sl-SI","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/"]}]},{"@type":"ImageObject","inLanguage":"sl-SI","@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/#primaryimage","url":"https:\/\/www.mylav.net\/wp-content\/uploads\/2022\/12\/blog_PIF_it.png","contentUrl":"https:\/\/www.mylav.net\/wp-content\/uploads\/2022\/12\/blog_PIF_it.png"},{"@type":"BreadcrumbList","@id":"https:\/\/www.mylav.net\/sl\/nekategorizirano-sl\/vrnitev-velike-klasike-macji-agp-alfa-1-kisli-glikoprotein\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.mylav.net\/sl\/"},{"@type":"ListItem","position":2,"name":"VRNITEV VELIKE KLASIKE: MA\u010cJI AGP (ALFA-1 KISLI GLIKOPROTEIN)"}]},{"@type":"WebSite","@id":"https:\/\/www.mylav.net\/sl\/#website","url":"https:\/\/www.mylav.net\/sl\/","name":"MyLav","description":"vicini al tuo veterinario, vicini alla tua famiglia","publisher":{"@id":"https:\/\/www.mylav.net\/sl\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.mylav.net\/sl\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"sl-SI"},{"@type":"Organization","@id":"https:\/\/www.mylav.net\/sl\/#organization","name":"MyLav","alternateName":"MyLav","url":"https:\/\/www.mylav.net\/sl\/","logo":{"@type":"ImageObject","inLanguage":"sl-SI","@id":"https:\/\/www.mylav.net\/sl\/#\/schema\/logo\/image\/","url":"https:\/\/www.mylav.net\/wp-content\/uploads\/2019\/02\/logo_mylav.svg","contentUrl":"https:\/\/www.mylav.net\/wp-content\/uploads\/2019\/02\/logo_mylav.svg","width":"1024","height":"1024","caption":"MyLav"},"image":{"@id":"https:\/\/www.mylav.net\/sl\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/laboratoriolavallonea\/","https:\/\/www.linkedin.com\/company\/mylav\/","https:\/\/www.youtube.com\/channel\/UCPinPLKBkenJ_QlDKxXXjCA","https:\/\/open.spotify.com\/show\/42D6N8rL6JzgjCfVnroMzp"]},{"@type":"Person","@id":"https:\/\/www.mylav.net\/sl\/#\/schema\/person\/1f212c868d6970154f91b93e9741dddb","name":"epops","image":{"@type":"ImageObject","inLanguage":"sl-SI","@id":"https:\/\/secure.gravatar.com\/avatar\/5b1686ccefcf94bad1a337443165cdc8836f3ded7fcc6aaf18c657018c423ad3?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/5b1686ccefcf94bad1a337443165cdc8836f3ded7fcc6aaf18c657018c423ad3?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/5b1686ccefcf94bad1a337443165cdc8836f3ded7fcc6aaf18c657018c423ad3?s=96&d=mm&r=g","caption":"epops"},"sameAs":["https:\/\/www.epops.it"]}]}},"_links":{"self":[{"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/posts\/25838","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/comments?post=25838"}],"version-history":[{"count":1,"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/posts\/25838\/revisions"}],"predecessor-version":[{"id":25839,"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/posts\/25838\/revisions\/25839"}],"wp:attachment":[{"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/media?parent=25838"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/categories?post=25838"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mylav.net\/sl\/wp-json\/wp\/v2\/tags?post=25838"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}