{"id":25828,"date":"2022-12-10T12:53:46","date_gmt":"2022-12-10T11:53:46","guid":{"rendered":"https:\/\/www.mylav.net\/nekategorizirano-sl\/le-retour-dun-grand-classique-lagp-alpha-1-glycoproteine-acide-feline\/"},"modified":"2024-02-08T18:02:59","modified_gmt":"2024-02-08T17:02:59","slug":"povratak-poznatog-klasika-macji-agp-alfa-1-glikoprotein","status":"publish","type":"post","link":"https:\/\/www.mylav.net\/hr\/nekategorizirano-sl\/povratak-poznatog-klasika-macji-agp-alfa-1-glikoprotein\/","title":{"rendered":"POVRATAK POZNATOG KLASIKA: MA\u010cJI AGP (ALFA-1 GLIKOPROTEIN)"},"content":{"rendered":"

Zarazni peritonitis ma\u010daka (FIP) je jedna od naj ra\u0161irenijih ma\u010djih zaraznih bolesti na svijetu i jo\u0161 uvijek predstavlja izazov veterinarima kada se radi o dijagnosticiranju. Kona\u010dna dijagnoza nije jednostavna \u201ein vivo\u201c jer trebaju biti uo\u010dene i klasi\u010dne klini\u010dko patolo\u0161ke promjene bolesti i sam uzro\u010dnik (koronavirus).<\/p>\n

Me\u0111u proteinima akutne faze, alfa-1 glikoproteinska kiselina (AGP) smatrala se du\u017ee vrijeme najkorisnijom za dijagnosticiranje FIP-a, ali tijekom zadnjih godina, metoda koja se koristi za njeno mjerenje (radialna imuno-difuzija) nije vi\u0161e dostupna.<\/p>\n

Napokon od 2023. godine, bit \u0107e mogu\u0107e u na\u0161em laboratoriju izmjeriti alfa-1-glikoprotenisku kiselinu (AGP) u ma\u010dijem serumu pomo\u0107u ELISA metode koja je nedavno potvr\u0111ena za tu \u017eivotninjsku vrstu.<\/p>\n

Alfa-1-glikoproteinska kiselina (AGP) je pozitivni protein akutne faze (APP). Njena koncentracija se pove\u0107ava tijekom upalnog procesa. Kod ma\u010daka, AGP se mo\u017ee mjeriti imunolo\u0161kim metodama npr. ELISA-om, ali one zahtijevaju antitijela specifi\u010dna za ma\u010dje proteine, jer uporaba antitijela koja su se razvila u drugim vrstama otkrivaju proteine koji nisu ma\u010dji AGP pa prema tome daju rezultate koji ne odgovaraju pravoj koncentraciji molekule. Du\u017ee vrijeme nije bilo mogu\u0107e to\u010dno odrediti AGP jer se radialni imunodifuzijski test koji se smatrao jedinim koji mo\u017ee prepoznati ma\u010dji AGP nije proizvodio. Me\u0111utim nedavno je razvijen jedan ELISA test s odgovaraju\u0107om preciznosti i to\u010dnosti za dijagnosti\u010dku uporabu. <\/p>\n

Me\u0111u proteinima akutne faze, AGP se pona\u0161a u gotovo svim \u017eivotinjskim vrstama kao manji ili umjereni APP. Njegova pove\u0107anja, drugim rije\u010dima, su kvantitativno ograni\u010dena: u slu\u010daju upalnog procesa, uo\u010davaju se pove\u0107anja 4 do 5 puta od normalne koncentracije (u krvi zdravih pojedinaca prisutan je u koli\u010dini manjoj od 0.5 mg\/mL kod gotovo svih vrsta).
\n\u010cak i kod ma\u010daka, AGP pokazuje umjerena pove\u0107anja u serumu u ve\u0107ini blagih ili ne specifi\u010dnih upalnih stanja. Izuzetak je zarazni peritonitis ma\u010daka (FIP), kod kojeg su pove\u0107anja koncentracije AGP-a u serumu \u010desto znatna (3 do 10 puta od normalne koncentracije).<\/p>\n

To \u010dini AGP vrlo mo\u0107nim dijagnosti\u010dkim alatom tijekom FIP-a, bilo suhog ili mokrog, i \u010dini ga najboljim markerom me\u0111u drugim APP-ovima, kako bi se razlikovala ova bolest od drugih upalnih ili zaraznih stanja sa sli\u010dnim simptomima. <\/p>\n

U stvari, iako se koncentracija drugih upalnih proteina kao \u0161to su serumski amiloid A (SAA) i haptoglobin (Hp) pove\u0107ava tijekom FIP-a, njihova pove\u0107anja su vrlo nespecifi\u010dna: SAA se na primjer pove\u0107ava zna\u010dajno (deset do sto puta od normalnih vrijednosti) i za vrijeme FIP-a i za vrijeme drugih upalnih bolesti. Nasuprot tome Hp pokazuje blago do umjereno pove\u0107anje za vrijeme FIP-a i za vrijeme drugih bolesti.<\/p>\n

Gore navedeni APP se prema tome ne mo\u017ee koristiti da bi se razlikovao FIP od drugih bolesti sa sli\u010dnom prezentacijom. Naravno, \u010dak i za vrijeme FIP-a mogu se primijetiti blaga pove\u0107anja AGP-a ali je to jo\u0161 uvijek iznad normalnih vrijednosti. U tom slu\u010daju, va\u017eno je povezati pove\u0107anja AGP-a sa simptomatskom slikom i sa svim drugim laboratorijskim promjenama koje su konzistentne s FIP-om posebice elektroforezom proteina u serumu, koja kod FIP-a pokazuje vrh alfa 2 i gama globulina, te citokemijskom slikom izlijeva (koja pokazuje visoki protein, albumin\/globulin omjer od <1. 0, visoki omjer LDH\/TNCC i nespecifi\u010dnu upalnu citologiju koju karakteriziraju uglavnom nedegenerativni neutrofili i pozadina granularnog proteina), vjerojatno u vezi s koronavirusom pozitivnim na PCR testu, koji iako mo\u017ee biti negativan kod otprilike tre\u0107ine ma\u010daka s FIP-om (PCR senzitivnosti kod izlijeva oko 70%), ako je pozitivan potvr\u0111uje dijagnozu (PCR specifi\u010dnost kod izlijevanja skoro 100%).\n\nPronala\u017eenje AGP vrijednosti unutar referentnog raspona, s druge strane, naj\u010de\u0161\u0107e isklju\u010duje FIP i poti\u010de na tra\u017eenje drugih uzroka za otkrivene simptome. Isto tako, mjerenje AGP-a ne poma\u017ee pri predvi\u0111anju ho\u0107e li se razviti FTP, ako se radi o zdravim ma\u010dkama koje su serolo\u0161ki pozitivne na koronavirus.\n\nAGP je u stvari upalni marker i \u010dak kada je ma\u010dka seropozitivna, serumske koncentracije ostaju normalne sve dok se ne razvije upala povezana s bolesti uzrokovanom koronavirusom. Drugim rije\u010dima, pove\u0107anje AGP-a se pojavljuje jedino nakon \u0161to su se pojavili simptomi, a ne prije. I na kraju, nedavno ispitivanje provedeno u zemljama gdje se analogna terapija nukleotidima propisuje i primjenjuje za borbu protiv FIP-a pokazalo je da se AGP obi\u010dno normalizira ranije nego svi drugi laboratorijski parametri kod ma\u010daka koje reagiraju na terapiju, dok je kod ma\u010daka kod kojih lije\u010denje na daje \u017eeljene rezultate ostaje nepromijenjen.\n\n\"PIF\"<\/p>\n

Prema tome, savjetuje se utvr\u0111ivanje AGP vrijednosti ne samo kod svakog upalnog procesa, kod kojih obi\u010dno ukazuje na blaga povi\u0161enja u skladu s drugim FIP-ovima, nego posebice kada otkriveni simptomi vode ka klini\u010dkoj sumnji da postoji suhi ili mokri FIP: ako su vrijednosti AGP-a unutar referentnih vrijednosti FIP se mo\u017ee isklju\u010diti, ako su s druge strane, te vrijednosti blago pove\u0107ane, FIP je mogu\u0107 ako ga druge klini\u010dke ili laboratorijske promjene potvr\u0111uju. Ako su vrijednosti pove\u0107ane, AGP mo\u017ee biti dijagnosti\u010dki alat koji potvr\u0111uje i kada je mogu\u0107e lije\u010denje s odobrenim antivirusnim lijekovima, mo\u017ee se smatrati idealnim markerom za nadzor terapije i identificiranje \u201eodzivnika\u201c.<\/p>\n

\n
Bibliografija:<\/h5>\n

Addie DD et al (2022) Alpha-1 Acid Glycoprotein Reduction Differentiated Recovery from Remission in a Small Cohort of Cats Treated for Feline Infectious Peritonitis (Oporavak diferenciran smanjivanjem alfa-1 kiseline glikoproteina nakon remisije u maloj skupini ma\u010daka lije\u010denih od ma\u010djeg infektivnog peritonitisa.). Virusi. Apr 1;14(4): 744. doi: 10.3390\/v14040744<\/p>\n

Hazuchova K et al (2017) Usefulness of acute phase proteins in differentiating between feline infectious peritonitis and other diseases in cats with body cavity effusions (Korisnost proteina akutne faze u razlikovanju ma\u010djeg infektivnog peritonitisa od drugih bolesti kod ma\u010daka s izljevima u tjelesne \u0161upljine). J Feline Med Surg. Aug;19(8):809-816. doi: 10.1177\/1098612X16658925. Epub 2016 Jul 18.<\/p>\n

Paltrinieri S et al (2007) Critical assessment of the diagnostic value of feline alpha1-acid glycoprotein for feline infectious peritonitis using the likelihood ratios approach (Kriti\u010dka procjena dijagnosti\u010dke vrijednosti ma\u010djeg alfa1-kiselinskog glikoproteina za ma\u010dji infektivni peritonitis primjenom pristupa omjera vjerojatnosti). J Vet Diagn Invest. May;19(3): 266-72.<\/p>\n

Saverio Paltrinieri<\/strong>, Vet. Doctor EBVS Europski stru\u010dnjak za veterinarsku klini\u010dku patologiju (Dipl. ECVCP); Universit\u00e0 di Milano
\nWalter Bertazzolo<\/strong>, Vet. Doctor EBVS Europski stru\u010dnjak za veterinarsku klini\u010dku patologiju (Dipl. ECVCP); MYLAV Direktor za znanost\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Zarazni peritonitis ma\u010daka (FIP) je jedna od naj ra\u0161irenijih ma\u010djih zaraznih bolesti na svijetu i […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-25828","post","type-post","status-publish","format-standard","hentry"],"acf":[],"yoast_head":"\nPOVRATAK POZNATOG KLASIKA: MA\u010cJI AGP (ALFA-1 GLIKOPROTEIN) - MyLav<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mylav.net\/hr\/nekategorizirano-sl\/povratak-poznatog-klasika-macji-agp-alfa-1-glikoprotein\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"POVRATAK POZNATOG KLASIKA: MA\u010cJI AGP (ALFA-1 GLIKOPROTEIN) - 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