{"id":31637,"date":"2025-05-19T15:43:48","date_gmt":"2025-05-19T13:43:48","guid":{"rendered":"https:\/\/www.mylav.net\/?p=31637"},"modified":"2025-05-19T15:43:48","modified_gmt":"2025-05-19T13:43:48","slug":"les-lymphomes-canins-a-double-phenotype-b-et-t-rares-mais-cliniquement-significatifs","status":"publish","type":"post","link":"https:\/\/www.mylav.net\/fr\/oncologie\/les-lymphomes-canins-a-double-phenotype-b-et-t-rares-mais-cliniquement-significatifs\/","title":{"rendered":"Les lymphomes canins \u00e0 double ph\u00e9notype B et T : rares mais cliniquement significatifs"},"content":{"rendered":"<p>Les lymphomes repr\u00e9sentent l&rsquo;une des tumeurs les plus fr\u00e9quentes chez le chien, mais certaines variantes se distinguent par des caract\u00e9ristiques inhabituelles qui posent des d\u00e9fis diagnostiques importants.<\/p>\n<p>Une \u00e9tude r\u00e9cente men\u00e9e par le d\u00e9partement d&rsquo;histopathologie du laboratoire MYLAV a analys\u00e9 33 cas rares de lymphome canin dans lesquels les cellules tumorales exprimaient simultan\u00e9ment des marqueurs \u00e0 la fois des cellules T et des cellules B \u2014 une condition connue sous le nom de \u00ab\u00a0double ph\u00e9notype\u00a0\u00bb (double positif).<\/p>\n<p><strong>Une anomalie rare mais cliniquement significative<\/strong><\/p>\n<p>Ces cas ont \u00e9t\u00e9 s\u00e9lectionn\u00e9s parmi plus de 4 000 diagnostics de lymphomes r\u00e9alis\u00e9s dans notre laboratoire sur une p\u00e9riode de cinq ans. Les sites les plus fr\u00e9quemment touch\u00e9s \u00e9taient la peau et les jonctions mucocutan\u00e9es (oro-nasales), avec une forte tendance \u00e0 l&rsquo;\u00e9pith\u00e9liotropisme (infiltration des \u00e9pith\u00e9liums), observ\u00e9e dans pr\u00e8s de la moiti\u00e9 des cas. La majorit\u00e9 des lymphomes \u00e9taient constitu\u00e9s de cellules lympho\u00efdes de taille moyenne \u00e0 grande, sugg\u00e9rant un comportement potentiellement agressif.<\/p>\n<p><strong><em>Figure 1.<\/em><\/strong><em> Aspects histologiques standards (A) et positivit\u00e9 aux marqueurs CD20 (B), CD3 (C) et CD5 (D) d&rsquo;un lymphome canin doublement positif.<\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31638 size-medium_large\" src=\"https:\/\/www.mylav.net\/wp-content\/uploads\/2025\/05\/fig1-768x606.jpg\" alt=\"\" width=\"768\" height=\"606\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Ph\u00e9notype ambigu : les r\u00e9sultats mol\u00e9culaires<\/strong><\/p>\n<p>D&rsquo;un point de vue immunoph\u00e9notypique, toutes les n\u00e9oplasies exprimaient CD3 (marqueur T) et CD20 (marqueur B), et presque toutes exprimaient \u00e9galement CD5. PAX5, un marqueur nucl\u00e9aire tr\u00e8s sp\u00e9cifique aux cellules B, \u00e9tait pr\u00e9sent dans seulement 36 % des cas.<\/p>\n<p>Une d\u00e9couverte particuli\u00e8rement int\u00e9ressante a \u00e9t\u00e9 la localisation aberrante de CD20 dans le cytoplasme des cellules tumorales dans pr\u00e8s de 90 % des cas, un sch\u00e9ma rarement observ\u00e9 dans des conditions physiologiques et associ\u00e9 \u00e0 des alt\u00e9rations mol\u00e9culaires complexes. L&rsquo;analyse clonale par PARR (PCR pour le r\u00e9arrangement des r\u00e9cepteurs d&rsquo;antig\u00e8ne) a confirm\u00e9 une pr\u00e9dominance de r\u00e9arrangements clonaux ou pseudoclonaux du r\u00e9cepteur T (TCR\u03b3) dans 70 % des cas, tandis que les aberrations du r\u00e9cepteur des immunoglobulines (CBmajor et CBminor) \u00e9taient pr\u00e9sentes dans seulement 27 % des cas, toujours sous forme pseudoclonale ou polyclonale.<\/p>\n<p>Aucun cas n&rsquo;a montr\u00e9 de r\u00e9arrangement clonal typique des cellules B, soutenant l&rsquo;hypoth\u00e8se que le diagnostic final dans ces cas \u00e9tait celui de lymphomes T avec une expression aberrante des marqueurs B.<\/p>\n<p><strong><em>Figure 2.<\/em><\/strong><em> Du point de vue cytomorphologique, les lymphomes doublement positifs pour les marqueurs T-cell et B-cell pr\u00e9sentent des caract\u00e9ristiques typiques des lymphomes T, avec des tailles variables, un cytoplasme clair parfois allong\u00e9 en forme de queue, un noyau arrondi ou indent\u00e9 avec une chromatine fine et des nucl\u00e9oles peu visibles.<\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-31645 size-medium_large\" src=\"https:\/\/www.mylav.net\/wp-content\/uploads\/2025\/05\/fig2-768x513.jpg\" alt=\"\" width=\"768\" height=\"513\" \/><\/p>\n<p><strong><br \/>\nImplications th\u00e9rapeutiques : pas seulement un diagnostic<\/strong><\/p>\n<p>Il est essentiel de souligner que le diagnostic pr\u00e9cis de ces lymphomes n&rsquo;est pas simplement un exercice acad\u00e9mique. Les implications cliniques sont consid\u00e9rables, notamment pour le choix du traitement :<\/p>\n<ul>\n<li>L&rsquo;expression de CD20 pourrait, en th\u00e9orie, rendre ces n\u00e9oplasmes sensibles \u00e0 des traitements immunoth\u00e9rapeutiques sp\u00e9cifiques aux cellules B, comme les anticorps monoclonaux anti-CD20 ou les vaccins autologues (APAVAC).<\/li>\n<li>Toutefois, la localisation principalement cytoplasmique de CD20 observ\u00e9e dans ces cas peut limiter l&rsquo;efficacit\u00e9 de ces traitements, qui agissent sur les antig\u00e8nes exprim\u00e9s \u00e0 la surface cellulaire.<\/li>\n<li>L&rsquo;origine T, confirm\u00e9e dans de nombreux cas par la PARR, sugg\u00e8re une r\u00e9ponse plus proche de celle des lymphomes T conventionnels, connus pour \u00eatre plus agressifs et moins r\u00e9actifs \u00e0 la chimioth\u00e9rapie classique compar\u00e9s aux lymphomes B.<\/li>\n<\/ul>\n<p>Malheureusement, les donn\u00e9es de suivi th\u00e9rapeutique \u00e9taient absentes, et des \u00e9tudes cliniques futures sont n\u00e9cessaires pour explorer la r\u00e9ponse de ces lymphomes \u00e0 des th\u00e9rapies combin\u00e9es ou \u00e0 de nouvelles approches mol\u00e9culaires cibl\u00e9es.<\/p>\n<p><strong>Conclusion<\/strong><\/p>\n<p>En conclusion, le diagnostic des lymphomes canins \u00e0 double ph\u00e9notype n\u00e9cessite une approche diagnostique int\u00e9gr\u00e9e combinant des techniques d&rsquo;immunohistochimie avanc\u00e9es avec des tests mol\u00e9culaires comme la PARR. Seul un panel \u00e9tendu de marqueurs T et B, associ\u00e9 \u00e0 une analyse clonale, peut \u00e9viter des erreurs diagnostiques et guider vers la strat\u00e9gie th\u00e9rapeutique la plus appropri\u00e9e. Cette \u00e9tude r\u00e9alis\u00e9e par l&rsquo;\u00e9quipe de MYLAV confirme l&rsquo;importance cruciale d&rsquo;une approche diagnostique sp\u00e9cialis\u00e9e et multidisciplinaire, essentielle pour relever les d\u00e9fis pos\u00e9s par les n\u00e9oplasies h\u00e9matologiques complexes chez le chien.<\/p>\n<p><strong>R\u00e9f\u00e9rence :<\/strong><\/p>\n<p>Mezzalira G et al. <em>Morphological, phenotypical and molecular characterization of canine lymphomas with dual T- and B-cell markers expression.<\/em> Frontiers in Veterinary Medicine 2025. <a href=\"https:\/\/doi.org\/10.3389\/fvets.2025.1578425\">https:\/\/doi.org\/10.3389\/fvets.2025.1578425<\/a><\/p>\n<p><strong>Giorgia Mezzalira<\/strong>, DMV, EBVS European Specialist in Veterinary Pathology (Dipl. ECVP); Pathologist at MYLAV<br \/>\n<strong>Luca Aresu<\/strong>, DMV, PhD, University of Turin, Head of Histopathology Service at MYLAV<\/p>\n<div>Source of the picture:\u00a0<a href=\"https:\/\/fr.freepik.com\/\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/fr.freepik.com\/&amp;source=gmail&amp;ust=1747724384627000&amp;usg=AOvVaw1IKfi99Anu0B_H0xmtFUkf\">https:\/\/fr.freepik.<wbr \/>com\/<\/a><\/div>\n<div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Les lymphomes repr\u00e9sentent l&rsquo;une des tumeurs les plus fr\u00e9quentes chez le chien, mais certaines variantes [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":31652,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1124],"tags":[],"class_list":["post-31637","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oncologie"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - 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